CompletedPhase 4

A Novel Role of Alpha Lipoic Acid in Comparison With Selenium in Mitochondrial Resuscitation and miRNA-126 Expression in Hemodialysis Patients

Egypt68 participantsStarted 2019-01-22

Plain-language summary

An Open labeled, Paralled, Randomized, Prospective, study was conducted on 60 patients who were randomized into 3 groups, 22, 20 and 18 patients in Control, Selenium and, Thiotacid groups respectively. Serum levels of ROS, CoQ10, and miRNA-126 were assessed at base line and after three months for all patients.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion Criteria: * prevalent hemodialysis patients Exclusion Criteria: * Patients with Inflammatory diseases, hepatic or respiratory diseases, smokers and alcoholics, were excluded from the study.

What they're measuring

Change in miRNA-126 level

Timeframe: 3 months

Change ROS level (ng/ml)

Timeframe: 3 months

Change in Co Q10 level (ng/ml)

Timeframe: 3 months

Trial details

NCT IDNCT05266794

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-04-23

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