ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough (NCT05265871) | Clinical Trial Compass
CompletedNot Applicable
ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough
China131 participantsStarted 2022-05-16
Plain-language summary
This is a cross-sectional study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory/unexplained chronic cough. 60 patients with refractory/unexplained chronic cough and 30 matched healthy controls were recruited. Demographic data, clinical characteristic, cough sacles and medical history records were collected. Cough chanllage(ATP and capsaicin) and ATP measurement in sputum were conducted.The difference of sputum ATP level between patients and control and the correlation between sputum ATP level and cough sensitivity to ATP were analyzed.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. ≥18 years old
✓. cough as sole symptom lasting ≥6 months
✓. cough visual analogue score ≥30mm
✓. diagnosed as RCC/UCC according to guidelines
Exclusion criteria
✕. smoking currently or in the past 6 months, or a smoking history of \>20 pack-year
✕. a forced expiratory volume in 1 second/forced vital capacity ratio \<70%;
✕. use of inhaled/oral corticosteroid, bronchodilators, anti-allergic medicine, antitussive medicine or anti-reflux treatment in the past 1 week;
✕. a history of acute respiratory infection in the past 4 weeks;
✕. a history of severe disease (cancer, acute coronary syndrome and so on).
✕. smoking currently or in the past 6 months, or a smoking history of \>20 pack-year
What they're measuring
1
ATP Level in Sputum Supernatant
Timeframe: ATP concentrations were measured in all specimens on the day of the last participant's enrollment.