CompletedNot Applicable

Aerobic Exercise Training in Patients With Chronic Hepatitis B and Hepatic Steatosis

Denmark19 participantsStarted 2022-03-14

Plain-language summary

This study is a randomised, controlled, unblinded, clinical intervention trial consisting of 12 weeks of aerobic exercise training. Thirty persons with chronic hepatitis B (CHB) and hepatic steatosis are randomised to either aerobic exercise training (intervention group, n=15) or no intervention (control group, n=15). The study will investigate the effects of the exercise intervention on the liver and the hypothesis is that the exercise group will reduce the fat-fraction of the liver after the intervention.

Who can participate

Age range30 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Chronic hepatitis B defined by HBsAg positive \>6 months * Positive HBV-DNA * Age \>30 * Hepatic steatosis diagnosed by Controlled Attenuated Parameter (CAP) \>250 assessed by Transient Elastography or by ultrasound defined hepatic steatosis Exclusion Criteria: * HIV, HCV, HDV-co infection * Primary biliary cholangitis * Wilsons Disease * Autoimmune hepatitis * Hepatocellular carcinoma * Antiviral medication * Steatogenic medication (systemic corticosteroids, amiodarone, tamoxifen, valproic acid, and methotrexate) * Average alcohol intake \>30 g for men and \>20 g for women pr. day * Contraindications for MRI scan * Coronary artery disease contraindicating HIIT * Unable to understand and read written information for participants written consent * Pregnancy

What they're measuring

Fat-Fraction of the Liver

Timeframe: From baseline to follow-up at 12 weeks

Trial details

NCT IDNCT05265026

SponsorRigshospitalet, Denmark

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09-30

View on ClinicalTrials.gov More Hepatitis B, Chronic trials