RecruitingNot Applicable

Cortical Excitability in Cyclic Vomiting Syndrome

United States110 participantsStarted 2022-05-16

Plain-language summary

This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS).

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * diagnosis of CVS Exclusion Criteria: * history of CVS (for healthy control population only) * psychosis or altered cognitive status * history of head injury, metal in the skull, stroke, or a history of seizures or a history of syncope (fainting or passing out) * implantable devices, such as a pacemaker or nerve stimulator * current use of the following medications or use of substances which are known to lower the seizure threshold: clozapine (Clozaril), chlorpromazine (Thorazine), amphetamines or methamphetamine, Ecstasy, Ketamine, Angel Dust/PCP, cocaine, or 3 or more alcoholic drinks per day * pregnancy

What they're measuring

Paired-pulse ratios

Timeframe: Multiple study sessions spanning up to 12 months

Trial details

NCT IDNCT05256160

SponsorUniversity of Pittsburgh

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-06

Contact for this trial

Paul HM Kullmann, PhD

412-647-1533 phmk@pitt.edu

View on ClinicalTrials.gov More Cyclic Vomiting Syndrome trials