By InvitationNot Applicable

Exercise Intervention in Patients With Heart Failure With Preserved and Reduced Ejection Fraction

Sweden120 participantsStarted 2022-06-01

Plain-language summary

The objective of this study is to assess by what physiological mechanisms patients with heart failure benefit from exercise. Effects of an exercise intervention will be assessed for both central (heart and lungs) and peripheral (muscle fiber and mitochondria) factors.

Who can participate

Age range50 Years – 90 Years

SexALL

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Inclusion criteria

✓. Signs and symptoms of heart failure
✓. Age ≥50 years
✓. Stable chronic heart failure (no hospitalizations within past month, no new medications past month)
✓. Able to understand and follow exercise prescription
✓. Currently physically inactive (less than 150 minutes/week moderate intensity exercise)

Exclusion criteria

✕. Currently or within the past 6 months been involved in cardiac rehab with exercise
✕. Devices or implants not compatible with magnetic resonance imaging or exercise testing
✕. Any orthopedic or medical condition affecting participation in testing and training
✕. Signs of acute ischemia during baseline cardiopulmonary exercise testing
✕. Participation in other clinical trials that may affect results
✕. Moderate or severe valvular disease
✕. Atrial fibrillation
✕. Moderate or severe chronic obstructive pulmonary disease

What they're measuring

Maximal oxygen uptake (VO2peak)

Timeframe: 12 weeks intervention

Trial details

NCT IDNCT05255172

SponsorRegion Skane

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-08-31

View on ClinicalTrials.gov More Heart Failure New York Heart Association (NYHA) Class II trials