UnknownEarly Phase 1

Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury

Egypt30 participantsStarted 2021-06-01

Plain-language summary

This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.

Who can participate

Age range

18 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Patients American Society of Anesthesiologists physical status (ASA) I to II.
. Patients Child Pugh classification A to B.
. Both sexes.
. Aged between 18 years and 70 years
. Scheduled for more than 1 segment hepatectomy.

Exclusion criteria

. Patients with Child Pugh classification C.
. Patients younger than18 years old or older than 70 years old
. Patients performed additional ablation therapies (cryosurgery or radiofrequency ablation).
. Prior liver resection for donation.
. Scheduled resection not requiring inflow occlusion (Pringle's maneuver).
. Hypersensitivity to any of the used drugs.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

aspartate aminotransferase (AST)

Timeframe: 1 week

alanine aminotransferase (ALT)

Timeframe: 1 week

bilirubin

Timeframe: 1 week

albumin

Timeframe: 1 week

prothrombin time

Timeframe: 1 week

INR

Timeframe: 1 week

Trial details

NCT IDNCT05246371

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-11-01

Contact for this trial

ola Lashin, Master

00201026034100 Ola.lashin@med.asu.edu.eg

View on ClinicalTrials.gov More Hepatectomy trials

Who can participate

Age range

18 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Patients American Society of Anesthesiologists physical status (ASA) I to II.
. Patients Child Pugh classification A to B.
. Both sexes.
. Aged between 18 years and 70 years
. Scheduled for more than 1 segment hepatectomy.

Exclusion criteria

. Patients with Child Pugh classification C.
. Patients younger than18 years old or older than 70 years old
. Patients performed additional ablation therapies (cryosurgery or radiofrequency ablation).
. Prior liver resection for donation.
. Scheduled resection not requiring inflow occlusion (Pringle's maneuver).
. Hypersensitivity to any of the used drugs.