UnknownEarly Phase 1

Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury

Egypt30 participantsStarted 2021-06-01

Plain-language summary

This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.

Who can participate

Age range18 Years – 70 Years

SexALL

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Inclusion criteria

✓. Patients American Society of Anesthesiologists physical status (ASA) I to II.
✓. Patients Child Pugh classification A to B.
✓. Both sexes.
✓. Aged between 18 years and 70 years
✓. Scheduled for more than 1 segment hepatectomy.

Exclusion criteria

✕. Patients with Child Pugh classification C.
✕. Patients younger than18 years old or older than 70 years old
✕. Patients performed additional ablation therapies (cryosurgery or radiofrequency ablation).
✕. Prior liver resection for donation.
✕. Scheduled resection not requiring inflow occlusion (Pringle's maneuver).
✕. Hypersensitivity to any of the used drugs.

What they're measuring

aspartate aminotransferase (AST)

Timeframe: 1 week

alanine aminotransferase (ALT)

Timeframe: 1 week

bilirubin

Timeframe: 1 week

albumin

Timeframe: 1 week

prothrombin time

Timeframe: 1 week

INR

Timeframe: 1 week

Trial details

NCT IDNCT05246371

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-11-01

Contact for this trial

ola Lashin, Master

00201026034100 Ola.lashin@med.asu.edu.eg

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