Recent evidence supports lymphatic regulation of tissue sodium handling, however fundamental gaps persist in knowledge regarding the role of lymphatics in human diseases of sodium dysregulation. The goal of this work is to apply novel, noninvasive imaging tools to measure relationships between lymphatic function and tissue sodium in patients with well-characterized lymphedema. Findings are intended to inform mechanisms of lymphatic clearance of tissue sodium, and provide novel imaging biomarkers of lymphedema progression and treatment response.
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Concentration of tissue sodium content
Timeframe: Baseline to completion of routine course of physical therapy (approximately 6 weeks)
Number of participants that changed lymphedema severity
Timeframe: Baseline to completion of routine course of physical therapy (approximately 6 weeks)
Concentration of tissue sodium content baseline
Timeframe: Baseline
Quantification of lymphatic states in extremities at baseline
Timeframe: Baseline