UnknownNot Applicable

Quantiative MRI and Myelin-PET for the Assessment of Degenerative Cervical Myelopathy

United Kingdom100 participantsStarted 2021-04-17

Plain-language summary

To use advanced imaging techniques, including MRI Brain and Spinal Cord, and MRI/PET Spinal Cord to provide an assessment of Degenerative Cervical Myelopathy to improve understanding of the pathophysiology and natural history of DCM.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Participant has a diagnosis of DCM, based on a combination of symptoms, signs and conventional MRI findings (Table 2)
✓. Participant is scheduled for surgical treatment for DCM
✓. Participant is willing and able to give informed consent for participation in the study;
✓. Male or Female, aged 18 - 85 years (inclusive);

Exclusion criteria

✕. Participant unable to give informed consent;
✕. Participant unable to undergo, or intolerant of MR or PET/MR imaging
✕. Participant has co-existing or prior neurological disease of the brain, spinal cord, or peripheral nervous system, including but not limited to, Lumbar Canal Stenosis, Multiple Sclerosis, Dementia and Parkinson's Disease.
✕. Contraindications to MRI: These are chiefly the presence of metallic implants that are not known to be MR safe, particularly in terms of movement or substantial heating. Devices that may need to be considered in this context include (this is not an exhaustive list, and this issue will be considered on a case-by-case basis for any implant or external fixation device):
✕. Female patients who are pregnant or breast-feeding
✕. Participants whose DCM surgery will include the insertion of metallic implants to secure multiple levels of the spine (technically termed 'instrumentation')
✕

What they're measuring

Modified Japanese Orthopaedics Association (mJOA)

Timeframe: 6 Months Post Surgery

Trial details

NCT IDNCT05242666

SponsorCambridge University Hospitals NHS Foundation Trust

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02-01

Contact for this trial

Benjamin Davies

01223 254517 benjamin.davies4@nhs.net

View on ClinicalTrials.gov More Cervical Spondylosis With Myelopathy trials