The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)

Inclusion Criteria: * acute (symptom onset to admission \<1 days) ischemic stroke * ischemic stroke affecting the branches of anterior cerebral artery, middle cerebral artery and posterior cerebral artery * age 18-80 years * moderate or severe stroke (National Institutes of Health Stroke Scale, NIHSS\>=5) * intravascular stroke treatment with thrombolysis or thrombectomy leading to satisfactory reperfusion (if applicable) * informed consent Exclusion Criteria: * secondary parenchymal hemorrhage (\>hemorrhage index -2) * clinically unstable or life-threatening conditions * known progressive neurological diseases * known psychiatric diseases * concomitant benzodiazepine medication * drug or alcohol abuse * pregnancy * disability to participate in the study * congestive heart failure with reduced ejection fraction (\<=45%) or New York Heart Association (NYHA) classification III-IV functional class