UnknownNot Applicable

Study on Opioid-free Anesthesia Protocol With S-ketamine and Propofol

China980 participantsStarted 2022-07

Plain-language summary

The purpose of this study was to observe the effects of opioid-free anesthesia with S-ketamine on postoperative analgesia and perioperative hemodynamics in short surgical operations, and to explore the effects of S-ketamine on postoperative awakening time and extubation time, nausea and vomiting, hypoxemia, and delirium.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion criteria

✓. Aged from 18 years to 65 years
✓. American society of anesthesiologists physical status classification I-II
✓. Patients scheduled for elective laparoscopic cholecystectomy
✓. Willing to sign informed consent

Exclusion criteria

✕. Allergic to narcotic drugs;
✕. Surgical history within the past 1 month;
✕. patients with neurological diseases or mental disorders;
✕. Unable to understand numerical rating Scale (NRS);
✕. patients with untreated or poorly controlled hypertension (arterial hypertension, resting systolic/diastolic blood pressure over 180/100mmHg);
✕. patients with untreated or undertreated hyperthyroidism;
✕. Patients with unstable angina pectoris or myocardial infarction in the past 6 months;
✕. When intraocular pressure is high (glaucoma) and penetrating ocular trauma, intraocular pressure cannot rise.

What they're measuring

The probability of numerical rating scale (NRS) score being less than or equal to 3 when leaving the Postanesthesia Care Unit (PACU)

Timeframe: 1 day of the surgery

Trial details

NCT IDNCT05242081

SponsorThe First Affiliated Hospital with Nanjing Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12

Contact for this trial

Ling Zhou

+86 15895918786 lingzhou531@foxmail.com

View on ClinicalTrials.gov More Opioid Use, Unspecified trials