Endoscopic variceal ligation (EVL) is used to control and prevent variceal bleeding in patients with liver cirrhosis, but it can be complicated by bleeding from post-EVL ulcers. the current study aims at evaluating the potential benefit of different acid-suppressive therapies in prevention of post band ligation ulcer/bleeding. We will include 234 patients with cirrhotic portal hypertension undergoing endoscopic band ligation. Patients will be randomly allocated into one group of acid suppressive therapy (Vonoprazan or pantoprazole) versus placebo for 14 days. Re-endoscopy will be done after 2 weeks of treatment to assess the healing of post ligation ulcers. Any form of upper gastrointestinal bleeding will be documented.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Post ligation ulcer : presence (Yes or No), number, and size
Timeframe: At 2 weeks after intervention (EBL)
Post endoscopic variceal ligation ulcers
Timeframe: At 2 weeks after intervention
Post endoscopic variceal ligation bleeding
Timeframe: during the 2 weeks treatment duration