Psilocybin-assisted Therapy for Phantom Limb Pain

Inclusion Criteria: * Between 18 and 75 years of age * Amputation of one extremity * Experience phantom limb pain of at least one month's duration and intensity of at least 3 out of 10 on the VAS * Able to fluently communicate in English * Agree to sign the consent and HIPPA authorization * Willing to refrain from taking serotonergic antidepressant medication during the study period * Willing to refrain from using any non-prescribed psychoactive drugs, including alcohol, within 24 hours before and after study drug administration * Agree not to use any nonprescription medications, herbal medications, or supplements during the week prior to each drug session unless an exception is approved by the study investigators * Willing to refrain from smoking or use of nicotine during the period from 8:00 am on the morning of the drug sessions until they are discharged to go home at the end of the end of the session * Able to remain in an MRI machine without sedation * Women of childbearing potential must agree to practice an effective means of birth control throughout the study, from screening to the final visit * Have a relative or friend who can provide/accompany transportation after the drug session * If pain is currently being treated with analgesic medications, the analgesic regimen must be stable for at least 2 weeks prior to enrollment, and the participant must agree not to change their use of analgesic medication without first consulting with the study investigators \[permissib…