CompletedNot Applicable

Effect of Nava on Weaning Outcome in Patients With Mechanical Ventilation

China130 participantsStarted 2022-01-26

Plain-language summary

This study intends to compare the effects of NAVA and PSV on weaning success rate and mechanical ventilation time in patients with tracheotomy patients through a randomized controlled study.

Who can participate

Age range18 Years – 85 Years

SexALL

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Inclusion criteria

✓. Tracheotomy and invasive mechanical ventilation is expected to be required for \> 48h;
✓. When support pressure ≤ 15 cmH2O, it can withstand pressure support ventilation (PSV) time \> 1h;

Exclusion criteria

✕. Age \< 18 years or \> 85 years;
✕. Deep sedation.
✕. Severe hemodynamic instability (norepinephrine or equivalent converted dose of other vasoactive drugs \> 1ug / kg.min or map ≤ 65mmhg)
✕. Severe respiratory center depression, high paraplegia, neuromuscular disease;
✕. Esophageal obstruction, esophageal perforation, severe esophageal variceal bleeding, upper gastrointestinal surgery, diaphragmatic hernia and thoracic deformity;
✕. Patients with chronic respiratory diseases requiring long-term home oxygen therapy;
✕. Patients with severe coagulation dysfunction (INR \> 1.5, APTT \> 44s, history of leukemia);
✕. Severe other organ dysfunction is expected to die in a short time (7 days) or palliative treatment.

What they're measuring

The 28-day ventilator-free days

Timeframe: From enrollment to days 28

Trial details

NCT IDNCT05219643

SponsorSoutheast University, China

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02-27

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