Association Between Persistent Organic Pollutants and Type 2 Diabetes /Thyroid Cancer (NCT05218395) | Clinical Trial Compass
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Association Between Persistent Organic Pollutants and Type 2 Diabetes /Thyroid Cancer
China900 participantsStarted 2021-12-20
Plain-language summary
Persistent organic pollutants (POPs) are a class of organic pollutants in the environment characterized by persistent, bioaccumulation, long-range transport and biological toxicity. Due to its widespread distribution in the environment and Lipophilicity, POPs can bioaccumulate along the food chain and eventually accumulate in the human body. There are many types of POPs, including dioxins, polychlorinated biphenyls (PCBs) , polybrominated diphenyl ethers (PBDEs) and organochlorine pesticides (OCPs) . POPs is ubiquitous and Lipophilic in the environment, so the potential harm of POPs to human body has aroused wide concern. A growing number of studies have found that exposure to POPs may be associated with an increased risk of endocrine disease, particularly type 2 diabetes and thyroid cancer.
The aim of this study was to assess the effect of Persistent organic pollutant exposure on the development ofType 2 diabetes and thyroid cancer by analyzing serum Persistent organic pollutant concentrations in controls, and patients with Type 2 diabetes and thyroid cancer.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. age 18 \~ 75 years old;
✓. type 2 diabetes patients diagnosed in the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) , HBA1C ≥7.0% and \<10.5% ;
✓. patients signed informed consent.
✓. age 18 \~ 75 years old;
✓. thyroid cancer patients diagnosed in the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) ;
✓. patients who signed the informed consent form.
✓. age 18 \~ 75 years old;
✓. healthy population recruited from the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) ;
Exclusion criteria
✕. patients with serious heart, liver and Kidney Diseases (related laboratory tests more than 2 times normal) ;
What they're measuring
1
To assess the risk of Persistent organic pollutant exposure to type 2 diabetes
Timeframe: 2021．11 Ethics Committee Approval 2021.12-2024.12 controls/patients recruitment, samples test 2025.1-2024.12 data analysis