CompletedNot Applicable

Exercise in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection Study

United States21 participantsStarted 2022-04-22

Plain-language summary

To examine the efficacy of an 8-week exercise training program on functional, cognitive, and emotional health outcomes compared to a no treatment control condition in adults with PASC.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18-65 years of age * Self-reported history of COVID-19 diagnosis * Self-reported ongoing symptoms of PASC \>4 weeks after initial infection Exclusion Criteria: * Neuromotor, musculoskeletal, or rheumatoid disorders that are exacerbated by exercise or conditions preventing cooperation * COVID-19 infection occurring \> 6 months prior to screening date * Contraindications to Symptom-limited Maximal Exercise Testing * Individuals without access to a device with iOS (apple devices such as iPhone, iPad, MacBook, etc.) * Patient-reported diagnosis of severe arterial hypertension * Patient reported metabolic disease * Patient reported uncontrolled asthma * Inmates * Pregnancy * Patient reported supplemental O2 use * Presence of beards * Patient reported diagnosis of claustrophobia * Non-English speaking

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Peak Oxygen Consumption (VO2max), mL/min

Timeframe: At first assessment, during week 1.

Peak Oxygen Consumption (VO2max), mL/min

Timeframe: At second assessment, during week 11.

Peak Oxygen Consumption (VO2max), mL/min

Timeframe: At third assessment, during week 20.

Score on Cognitive Function Self-Assessment Scale (CFSS)

Timeframe: At first assessment, during week 1.

Score on Cognitive Function Self-Assessment Scale (CFSS)

Timeframe: At second assessment, during week 11.

Score on Cognitive Function Self-Assessment Scale (CFSS)

Timeframe: At third assessment, during week 20.

Score on PHQ-8

Timeframe: At first assessment, during week 1.

Trial details

NCT IDNCT05218174

SponsorBaylor Research Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-11-17

View on ClinicalTrials.gov More COVID-19 trials

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Peak Oxygen Consumption (VO2max), mL/min

Timeframe: At first assessment, during week 1.

Peak Oxygen Consumption (VO2max), mL/min

Timeframe: At second assessment, during week 11.

Peak Oxygen Consumption (VO2max), mL/min

Timeframe: At third assessment, during week 20.

Score on Cognitive Function Self-Assessment Scale (CFSS)

Timeframe: At first assessment, during week 1.

Score on Cognitive Function Self-Assessment Scale (CFSS)

Timeframe: At second assessment, during week 11.

Score on Cognitive Function Self-Assessment Scale (CFSS)

Timeframe: At third assessment, during week 20.

Score on PHQ-8

Timeframe: At first assessment, during week 1.