UnknownNot Applicable

High Flow Nasal Cannula Versus High Velocity Nasal Insufflation in Covid-19

50 participantsStarted 2022-03

Plain-language summary

To compare the outcomes of HFNC and HVNI in COVID-19 patients with acute respiratory failure as regard need for mechanical ventilation, changes of arterial blood gases (ABG) parameters, duration of ventilatory support and delay between admission and intubation

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * COVID-19 positive by RT-PCR * Age≥ 18 years * Both gender * Classical radiological lesions of COVID-19 on HRCT chest. * Respiratory rate \> 30/ min and not responding to non-rebreather masks. * COVID-related pneumonia requiring non-invasive ventilatory support (high-flow nasal cannula, and / or non-invasive ventilation and / or CPAP) Exclusion Criteria: * Age \< 18 years * Patients who refuse to participate in the study * Severe respiratory failure requiring invasive ventilatory support * Indication of immediate tracheal intubation * Significant acute progressive circulatory insufficiency * Impaired conscious level * Nasal blockade

What they're measuring

To compare the outcomes of HFNC and HVNI in COVID-19 patients with acute respiratory failure

Timeframe: baseline

changes of arterial blood gases (ABG) parameters

Timeframe: within 2 hours then according to clinical condition

duration of ventilatory support

Timeframe: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months

delay between admission and intubation.

Timeframe: baseline

Trial details

NCT IDNCT05216640

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-03

Contact for this trial

Basma A Mohammed, MD

+0201067620044 Basma.20133938@med.au.edu.eg

View on ClinicalTrials.gov More COVID-19 trials

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

To compare the outcomes of HFNC and HVNI in COVID-19 patients with acute respiratory failure

Timeframe: baseline

changes of arterial blood gases (ABG) parameters

Timeframe: within 2 hours then according to clinical condition

duration of ventilatory support

Timeframe: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months

delay between admission and intubation.

Timeframe: baseline