UnknownNot Applicable

High Flow Nasal Cannula Versus High Velocity Nasal Insufflation in Covid-19

50 participantsStarted 2022-03

Plain-language summary

To compare the outcomes of HFNC and HVNI in COVID-19 patients with acute respiratory failure as regard need for mechanical ventilation, changes of arterial blood gases (ABG) parameters, duration of ventilatory support and delay between admission and intubation

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * COVID-19 positive by RT-PCR * Age≥ 18 years * Both gender * Classical radiological lesions of COVID-19 on HRCT chest. * Respiratory rate \> 30/ min and not responding to non-rebreather masks. * COVID-related pneumonia requiring non-invasive ventilatory support (high-flow nasal cannula, and / or non-invasive ventilation and / or CPAP) Exclusion Criteria: * Age \< 18 years * Patients who refuse to participate in the study * Severe respiratory failure requiring invasive ventilatory support * Indication of immediate tracheal intubation * Significant acute progressive circulatory insufficiency * Impaired conscious level * Nasal blockade

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

To compare the outcomes of HFNC and HVNI in COVID-19 patients with acute respiratory failure

Timeframe: baseline

changes of arterial blood gases (ABG) parameters

Timeframe: within 2 hours then according to clinical condition

duration of ventilatory support

Timeframe: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months

delay between admission and intubation.

Timeframe: baseline

Trial details

NCT IDNCT05216640

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-03

Contact for this trial

Basma A Mohammed, MD

+0201067620044 Basma.20133938@med.au.edu.eg

View on ClinicalTrials.gov More COVID-19 trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

To compare the outcomes of HFNC and HVNI in COVID-19 patients with acute respiratory failure

Timeframe: baseline

changes of arterial blood gases (ABG) parameters

Timeframe: within 2 hours then according to clinical condition

duration of ventilatory support

Timeframe: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months

delay between admission and intubation.

Timeframe: baseline