CompletedNot Applicable

Interhemispheric Connectivity and Compensation

United States120 participantsStarted 2021-12-09

Plain-language summary

The goal of this study is to determine which parts of the brain make it possible for some people to move skillfully with their left non-dominant hand.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age ≥ 18
✓. English speaking and reading
✓. Able to fit in Prisma scanner bore (60 cm diameter)
✓. Right hand dominant (self report, and Edinburgh handedness ≥ +40)
✓. Chronic unilateral upper extremity peripheral nerve injury to the right side
✓. Some impairment to writing, requiring both of:

Exclusion criteria

✕. Currently intoxicated or otherwise non-compliant
✕. Chronic pain diagnosis unrelated to the nerve injury
✕. Uncorrected visual impairment that interferes with ability to see drawings in MRI
✕. Motor function diagnoses that affect function of the left hand, now or in past 2 years
✕. Motor function diagnoses currently affecting the right hand, unrelated to the nerve injury
✕. Upper extremity surgery, including peripheral nerve surgery, within last 2 months
✕. Contraindication for MRI
✕. Contraindication for transcranial magnetic stimulation (TMS)

What they're measuring

BOLD (blood oxygen level dependent) signal in ROIs (regions of interest)

Timeframe: Day 1

Trial details

NCT IDNCT05207878

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-01

View on ClinicalTrials.gov More Peripheral Nerve Injury Upper Limb trials