RecruitingNot Applicable

Comparison of the Therapeutic Effects of Vaginal Repair With Leuprorelin and Vaginal Repair in the Treatment of Cesarean Section Scar Defect

China94 participantsStarted 2023-05-01

Plain-language summary

GnRH-a will be used to postpone period after vaginal repair for Cesarean Section Scar Defect（CSD） patients with adenomyosis which will be compared with CSD patients with adenomyosis who receive transvaginal surgery without GnRH-a, whether delayed period improving the CSD prognosis will be assessed.

Who can participate

Age range18 Years – 50 Years

SexFEMALE

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Inclusion criteria

✓. Clearly diagnosed with CSD complicated with adenomyosis
✓. Experiencing clinical features of abnormal uterine bleeding, prolonged menstrual flow (the duration of menstruation is more than 10 days).
✓. The thickness of the remaining muscular layer of CSD was less than 3 mm.
✓. Normal range of blood sugar and insulin
✓. No serious medical problems (important viscera function in the normal range).
✓. uterine fibroids no more than 5cm
✓. Sign the informed consent.

Exclusion criteria

✕. Indefinite diagnosis.
✕. Malignant tumors.
✕. With severe medical problems (severe liver disease, kidney disease, respiratory diseases, heart disease or uncontrolled diabetes, epilepsy, etc., dysfunction of important organs).
✕. Pregnant.
✕. Mental diseases.
✕. Allergy to the any ingredients of Leuprorelin
✕. Unwilling to comply with the research plan.

What they're measuring

thickness of the remaining muscular layer (TRM) (mm)

Timeframe: 12 weeks after vaginal repair of CSD

Duration of menstruation (day)

Timeframe: 12 weeks after vaginal repair of CSD

Trial details

NCT IDNCT05206682

SponsorXinhua Hospital, Shanghai Jiao Tong University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-04-30

Contact for this trial

Wang Xipeng

+862125078999 steveoizzie@icloud.com

View on ClinicalTrials.gov More Cesarean Section; Dehiscence trials