RecruitingNot Applicable

Interventions in Mathematics and Cognitive Skills

United States180 participantsStarted 2023-05-05

Plain-language summary

The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).

Who can participate

Age range6 Years – 12 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Elementary school aged children starting from first grade (6-12 years old)
✓. IQ: Participants with a Full Scale IQ \> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).
✓. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests
✓. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests
✓. Normal or corrected-to-normal vision and no hearing impairments
✓. Inclusion in MRI scan session: Right-handed

Exclusion criteria

✕. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.)
✕. History of trauma involving head injury
✕. Consistent psychiatric medications
✕. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)

What they're measuring

Change from baseline in symbolic number comparison task performance (reaction time)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in symbolic number comparison task performance (accuracy)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in non-symbolic number comparison task performance (reaction time)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in non-symbolic number comparison task performance (accuracy)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in latent cognitive measures of symbolic number comparison task performance (drift rate)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in latent cognitive measures of symbolic number comparison task performance (post-error adjustment)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in latent cognitive measures of non-symbolic number comparison task performance (drift rate)

Timeframe: Baseline and post-intervention (after 6 weeks)

Trial details

NCT IDNCT05201534

SponsorStanford University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-30

Contact for this trial

Vinod Menon, PhD

16507363699 menon@stanford.edu

View on ClinicalTrials.gov More Math Learning Disability trials

Who can participate

Age range6 Years – 12 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Elementary school aged children starting from first grade (6-12 years old)
✓. IQ: Participants with a Full Scale IQ \> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).
✓. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests
✓. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests
✓. Normal or corrected-to-normal vision and no hearing impairments
✓. Inclusion in MRI scan session: Right-handed

Exclusion criteria

✕. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.)
✕. History of trauma involving head injury
✕. Consistent psychiatric medications
✕. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)

What they're measuring

Change from baseline in symbolic number comparison task performance (reaction time)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in symbolic number comparison task performance (accuracy)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in non-symbolic number comparison task performance (reaction time)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in non-symbolic number comparison task performance (accuracy)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in latent cognitive measures of symbolic number comparison task performance (drift rate)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in latent cognitive measures of symbolic number comparison task performance (post-error adjustment)

Timeframe: Baseline and post-intervention (after 6 weeks)

Change from baseline in latent cognitive measures of non-symbolic number comparison task performance (drift rate)

Timeframe: Baseline and post-intervention (after 6 weeks)