Objective: To investigate the effect of Chinese herbal medicine (CHM) as an adjuvant therapy in the treatment of traumatic anosmia. Methods: Patients with a clear history of loss of smell after head injury, and whose phenyl ethyl alcohol (PEA) odor detection threshold remained -1 after treatment with steroid, zinc, and olfactory training (OT) for one month, were included in this study between September of 2018 and November of 2020. They were randomly divided into 2 groups, with patients in the CHM group taking CHM (tailored Guizhi decoction) and performing OT, and those in the OT group receiving OT only for 6 months. After 3 months' and 6 months' treatment, the olfactory function was evaluated by both the PEA threshold test and the traditional Chinese version of the University of Pennsylvania Smell Identification Test (UPSIT-TC). Magnetic resonance imaging was performed to measure the volume of olfactory bulbs after 6 months' treatment.
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Olfactory test - Birhinal PEA threshold (3 months after treatment)
Timeframe: Change between before treatment and 3 months after treatment
Olfactory test - Birhinal PEA threshold (6 months after treatment)
Timeframe: Change between before treatment and 6 months after treatment
Olfactory test - UPSIT-TC (3 months after treatment)
Timeframe: Change between before treatment and 3 months after treatment
Olfactory test - UPSIT-TC (6 months after treatment)
Timeframe: Change between before treatment and 6 months after treatment
The volume of olfactory bulbs
Timeframe: 6 months after treatment