RecruitingNot Applicable

Association of Intrahepatic Cholestasis of Pregnancy and Chronic Placental Inflammation

France322 participantsStarted 2022-06-21

Plain-language summary

This observational prospective study will help to determine if an immune process similar to allograft rejection is responsible for the occurrence of an intrahepatic cholestasis of pregnancy (ICP). If so, it would suggest the potential benefit of immunomodulatory therapeutics.

Who can participate

Age range18 Years – 60 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult pregnant woman with singleton For cases: diagnosis of intrahepatic cholestasis of pregnancy For controls: no diagnosis of ICP Exclusion Criteria: * Women under 18 years old * Women under legal protection * Gemellar pregnancies * Delivery before 22 Weeks of gestation * Medical termination of pregnancy * Acute chorioamniotitis, in particular those due to the following pathogens: toxoplasmosis, rubella, CMV, herpes virus * Premature rupture of membranes \<37SA * Women infected by covid-19 in the month before delivery

What they're measuring

Prevalence of placental chronic inflammation

Timeframe: At delivery

Trial details

NCT IDNCT05197387

SponsorUniversity Hospital, Brest

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06-21

Contact for this trial

Claire de Moreuil

02 98 14 53 03 claire.demoreuil@chu-brest.fr

View on ClinicalTrials.gov More Cholestasis of Pregnancy trials