CompletedNot Applicable

Mapping the Human Colon Using Single Cell Sequencing

Denmark40 participantsStarted 2022-07-01

Plain-language summary

The overall purpose of this study is to describe the cellular composition of the human colon and its gene expression using scRNAseq and scATACseq methods. This will potentially provide is with a detailed map of the colon aiding our understanding of how diseases of the colon develop as well as the colons influence on systemic diseases such as type II diabetes.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients referred for out-patient colonoscopy as a result of positive hemoccult. * Patients able to read and understand danish. * Patients able to give informed consent. * Patients of Scandinavian ethnicity. Exclusion Criteria: * Previous large bowel resections * Suspicion pre or intraoperatively of benign or malignant disease of the colon * Known inflammatory bowel disease. * Immuno-modulation treatment * Chemotherapy. * Daily smoking * \> 21 weekly units of alcohol * \< 18 years of age

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Profiling of open chromatin regions

Timeframe: 2 years

Evaluation of metabolic profile

Timeframe: 2 years

Trial details

NCT IDNCT05195502

SponsorBispebjerg Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-12-31

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