CompletedNot Applicable

The Effects of Orchiectomy and Age on Vascular and Metabolic Health in Older Versus Younger Transgender Women

United States17 participantsStarted 2021-03-22

Plain-language summary

This study plans to learn more about differences in heart disease risk after gender-affirming orchiectomy (i.e., testes removal) in older transgender (trans) women compared to younger trans women.

Who can participate

Age range

18 Years – 99 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged 18 years and older * Identify as a transgender woman * Have taken estradiol and spironolactone for at least one year * Currently taking oral or transdermal or injectable estradiol * Have not yet undergone but desire orchiectomy Exclusion Criteria: * Under 18 years of age * Don't identify as a transgender woman * Not currently taking estradiol or spironolactone * Have been on estradiol and spironolactone for less than one year * History of orchiectomy * Not deemed a candidate for orchiectomy * Current tobacco smoker * Current illicit drug use * History of prior or active estrogen-dependent neoplasms * Acute liver or gallbladder disease * Venous thromboembolism * Hypertriglyceridemia \>500 mg/dL * Fasted plasma glucose \>7.0 mmol/L or previously treated diabetes * Resting blood pressure \>140/90 mmHg

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Evaluation of endothelial function (flow-mediated dilation (FMD) at Baseline

Timeframe: Baseline

Evaluation of endothelial function (flow-mediated dilation (FMD) at 1 Month

Timeframe: 1 month

Evaluation of endothelial function (flow-mediated dilation (FMD) at 6 Months

Timeframe: 6 month

Evaluation of endothelial function (flow-mediated dilation (FMD) at 12 Months

Timeframe: 12 month

Trial details

NCT IDNCT05195164

SponsorUniversity of Colorado, Denver

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-12-31

View on ClinicalTrials.gov More Transgender trials