Manufacturing, Characterization and Evaluation of the Effect of Silk Fibroin Membranes, Loaded or Not With Neurotensins on Open Wounds in the Palate

Inclusion Criteria: * Patients at least 18 years old, healthy systemically, with good oral hygiene, assessed by means of a plaque index and gingival index less than 25% (O'Leary et al., 1972) * Patients with no morphological or pathological changes in the donor palatal region; * Patients who have an indication for extraction and with an indication to preserve the socket for future implant installation; * The tooth included in the study, as well as the adjacent teeth, must not have loss of periodontal insertion. Exclusion Criteria: * Patients with systemic problems (cardiovascular changes, blood dyscrasias, immunodeficiency, diabetes, among others), who contraindicate the surgical procedure; * Patients who use medications that interfere with wound healing; * Pregnant or lactating patients; * Patients who present opportunistic oral lesions, mainly colonizing the palate region; * Smoking patients; * Patients undergoing orthodontic treatment; * Patients already submitted to periodontal surgery in the area of interest in the present study; * Patients with a history of allergy to any type of material used in the present study.