Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr) (NCT05190432) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)
United Kingdom90 participantsStarted 2021-11-10
Plain-language summary
The complexities of the immune system make measuring the impact of dietary interventions upon its function challenging. The immune system is highly responsive to environmental influences, including the diet. An individual's diet provides the energy required to mount a strong and protective immune response, the building blocks required for synthesis of immune mediators such as antibodies and cytokines, and can also indirectly affect immune function via changes in the gut microbiome. Immune function varies across the lifecourse, with a well understood decline in immune function with age, resulting in impaired vaccination responses and an increased risk of infections and of severe complications and mortality arising from common communicable diseases such as influenza. This impaired immunity with ageing is known as immunosenescence and this affects both innate and acquired arms of the immune system.
Who can participate
Age range
50 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* age 50-65yr
* BMI 18.5-30kg/m2
* Willing to avoid consumption of foods rich in Taxifolin/DHQ and Ergothioneine during the study period
* Willing to avoid taking any other food supplements or high doses of vitamins during the study period
* Able to provide written informed consent.
Exclusion Criteria:
* Use of prescription medication which may influence immune function, such as anti-inflammatory or immunosuppressant medication
* Diabetes requiring any medication
* Liver cirrhosis
* A history of drug or alcohol misuse
* Asplenia or other acquired or congenital immunodeficiencies
* Any autoimmune disease including connective tissue diseases
* Malignancy
* Laboratory confirmed SARS-CoV-2 infection within last 3 months
* self-reported symptoms of acute or recent infection (including use of antibiotics within the last 3 months)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.