CompletedNot Applicable

Ventilatory Responses to Hypercapnic and Hypoxic Conditions in Hyperventilants

Belgium24 participantsStarted 2021-10-15

Plain-language summary

For almost a century, many hypotheses have converged on the idea of altered chemosensitivity in patients suffering from hyperventilation syndrome (HVS). Given the evolution of current technical equipment and the ability to maximise true positives in HVS ( using the revised hyperventilation provocation test), it seems reasonable to investigate central and peripheral chemosensitivities in HVS subjects.

Who can participate

Age range

18 Years – 99 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * A plethysmography within subject's predicted values * A negative metacholine test (no documented allergy) * A hyperventilation provocation test result that is consistent with the Nijmegen questionnaire score, confirming either group classification (HVS+ or HVS-) Exclusion Criteria: * Each of the following known or documented conditions: chronic bronchitis (COPD), emphysema, asthma, cardiac disorder, neurological disorder, gastrointestinal disorder, thyroid disorder or psychological/psychiatric disorder * Suspicious cardio-pulmonary exercise testing (CPET) with cardiac or respiratory limitation * Pregnant women or women in the process of becoming pregnant * Persons with a diving practice (amateur or professional), * High-level athletes, * Active smokers and * persons using morphine, and/or barbiturates, and/or anxiolytics and/or sleeping pills

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The slope of the ventilatory response to hypercapnia (HCVR)

Timeframe: baseline - during the test

The slope of the ventilatory response to hypoxia (HOVR)

Timeframe: baseline - during the test

Ventilatory recruitment threshold (VRT) of the HCVR

Timeframe: baseline - during the test

Ventilatory recruitment threshold (VRT) of the HOVR

Timeframe: baseline - during the test

Trial details

NCT IDNCT05189158

SponsorCentre Hospitalier Universitaire Saint Pierre

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-10-15

View on ClinicalTrials.gov More Hyperventilation Syndrome trials

Plain-language summary

Who can participate

Age range

18 Years – 99 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

The slope of the ventilatory response to hypercapnia (HCVR)

Timeframe: baseline - during the test

The slope of the ventilatory response to hypoxia (HOVR)

Timeframe: baseline - during the test

Ventilatory recruitment threshold (VRT) of the HCVR

Timeframe: baseline - during the test

Ventilatory recruitment threshold (VRT) of the HOVR

Timeframe: baseline - during the test