Comparison of IntraArticular Platelet-Rich-Plasma to Corticosteroid Injections for Patients With … (NCT05188820) | Clinical Trial Compass
CompletedNot Applicable
Comparison of IntraArticular Platelet-Rich-Plasma to Corticosteroid Injections for Patients With Zygapophyseal Joint (Z-Joint) Low Back Pain Confirmed by Dual Intra-Articular Local Anesthetic Injections
Canada50 participantsStarted 2022-04-01
Plain-language summary
Comparison of IntraArticular Platelet-Rich-Plasma to Corticosteroid Injections for Patients with Zygapophyseal Joint (Z-Joint) Low Back Pain Confirmed by Dual Intra-Articular Local Anesthetic Injections: A Triple Blinded Randomized Controlled Trial.
Who can participate
Age range40 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* \- 40 years old or more; given the low prevalence of facet pain in younger adults
* LBP present for more than six months, with an axial predominance
* Persistent LBP after three months of non-interventional treatment
* Pretreatment ODI score of at least 30/100 (moderate disability associated with LBP)
* Pretreatment LBP VAS of at least 4/10
* 80% LBP reduction 30 minutes after 2 intra-articular diagnostic blocs with Xylocaine and Marcaine
* Radiological signs of facet joint degeneration (on X-rays, CT Scan or MRI)
* Absence of neurological deficit
* Sufficient knowledge of French or English to complete the questionnaires
Exclusion Criteria:
* \- Less than 40 years old
* Failure to achieve intra-articular diagnostic block
* Intra-articular injection of CS 3 months or less before recruitment
* Oral corticosteroid use in the last two weeks
* Inflammatory disease
* Systemic infection
* Infection at injection site
* Vertebral fracture
* Spine tumour
* Surgical intervention at injection site prior to the study or planned
* Cognitive disorder that impairs the ability to answer the questionnaires
* Pregnancy
* Breastfeeding
* Coagulopathy affecting platelets
* Drug affecting platelets that cannot be stopped (except acetylsalicylic acid)
* Intolerance or allergies to local anesthetics, contrast agent, CS, and blood products