Mechanisms and Biomarkers for Tumor Immunogenicity Modulation in Cervical Cancer

Inclusion Criteria: * Pathological proven diagnosis of cervical cancer or benign gynecologic tumor and will undergoing panhysterectomy or pathological proven diagnosis of cervical cancer and will undergoing radiotherapy * Tumor accessible for biopsy during the course of radiotherapy or tumor samples could be obtained via surgery * Patient must provide study-specific informed consent prior to study entry Exclusion Criteria: * History of autoimmune diseases * History of immunotherapy * History of pelvic radiotherapy * Will receive immunotherapy during the course of treatment * Contraindications for biopsy, such as high bleeding risk