(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With I… (NCT05186753) | Clinical Trial Compass
Active — Not RecruitingPhase 2
(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis
United States237 participantsStarted 2022-06-27
Plain-language summary
This is a multi-part, randomized, double-blind, placebo-controlled Phase 2 clinical study comparing the safety and efficacy of bezuclastinib (CGT9486) plus best supportive care (BSC) with placebo plus BSC in patients with nonadvanced systemic mastocytosis (NonAdvSM), including indolent systemic mastocytosis and smoldering systemic mastocytosis, whose symptoms are not adequately controlled by BSC. This study will be conducted in three parts. Patients in Parts 1a, 1b and 2 will receive bezuclastinib or placebo, and may roll over onto Part 3 to receive treatment with bezuclastinib. Additionally, a substudy of subjects will investigate the efficacy, safety, and tolerability of bezuclastinib in patients who are experiencing inadequate symptom control with avapritinib.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Diagnosed with 1 of the following diagnoses according to the 2016 World Health Organization (WHO) classification for systemic mastocytosis (SM):
✓. Moderate-to-severe symptoms based on a minimum total symptom scoew (TSS) of the Mastocytosis Activity Score (MAS) and after establishing a stable regimen of at least 2 antimediator therapies over a 14-day eligibility period
✓. Eastern Cooperative Oncology Group (ECOG) Performance Status 0 to 2
✓. For patients receiving corticosteroids, the dose must be ≤10 mg/day of prednisone or equivalent
Exclusion criteria
✕. Persistent toxicity from previous therapy for NonAdvSM that has not resolved to ≤ Grade 1
✕. Diagnosed with any of the following WHO SM classifications: bone marrow mastocytosis, advanced systemic mastocytosis including SM with associated hematologic neoplasm, aggressive SM, mast cell leukemia; or mast cell sarcoma
✕. Diagnosed with mastocytosis of the skin without systemic involvement
✕. Received prior treatment with any targeted KIT inhibitor with the exception of approved agents for the treatment of SM
What they're measuring
1
Part 1: Determine recommended dose of bezuclastinib (CGT9486) in subjects with NonAdvSM
Timeframe: 3 months
2
Part 2: Efficacy of bezuclastinib at the selected dose versus placebo
Timeframe: 24 Weeks
3
Part 3: Safety and tolerability of bezuclastinib as assessed by number of adverse events
✕. Received prior cytoreductive therapy or investigational agent for \<14 days or 5 half- lives of the drug and for cladribine, interferon alpha, pegylated interferon, or antibody therapy \<28 days or 5 half-lives of the drug (whichever is longer), before starting screening assessments
✕. Received radiotherapy or psoralen and ultraviolet A therapy \<14 days before starting screening assessments
✕. Received any hematopoietic growth factor support \<14 days or 5 half lives of the drug before starting screening assessments
✕. History of clinically significant bleeding event within 30 days before the first dose of study drug or need for therapeutic anticoagulation on study