CompletedNot Applicable

Comparison of the Genotoxicity of Desflurane and Propofol

Turkey (Türkiye)30 participantsStarted 2022-01-17

Plain-language summary

The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Ability to understand and willingness to sign an informed consent form
✓. Elective lumbar spinal surgery that will take at least 120 minutes,
✓. American Society of Anesthesiologists (ASA) physical status I and II

Exclusion criteria

✕. Patients with ASA physical status III or IV disease
✕. Chronic systemic disease (diabetes mellitus,chronic pulmonary disorders, chronic kidney and liver disorders)
✕. Smoking or alcohol consumption
✕. Recently received radiation, chemotherapy
✕. Malignancy
✕. Patients who will receive blood transfusion during the operation
✕. Users of antioxidant supplements
✕. Patients who have received general anesthesia in the last three months

What they're measuring

Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: Before anesthesia induction

Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: 2 hours after anesthesia induction

Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: postoperative 1st day

Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: postoperative 5th day

Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: Before anesthesia induction

Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: 2 hours after anesthesia induction

Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: postoperative 1 st day

Trial details

NCT IDNCT05185167

SponsorMuğla Sıtkı Koçman University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-03-15

View on ClinicalTrials.gov More DNA Damage trials

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Ability to understand and willingness to sign an informed consent form
✓. Elective lumbar spinal surgery that will take at least 120 minutes,
✓. American Society of Anesthesiologists (ASA) physical status I and II

Exclusion criteria

✕. Patients with ASA physical status III or IV disease
✕. Chronic systemic disease (diabetes mellitus,chronic pulmonary disorders, chronic kidney and liver disorders)
✕. Smoking or alcohol consumption
✕. Recently received radiation, chemotherapy
✕. Malignancy
✕. Patients who will receive blood transfusion during the operation
✕. Users of antioxidant supplements
✕. Patients who have received general anesthesia in the last three months

What they're measuring

Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: Before anesthesia induction

Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: 2 hours after anesthesia induction

Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: postoperative 1st day

Intensity of the DNA tail detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: postoperative 5th day

Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: Before anesthesia induction

Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: 2 hours after anesthesia induction

Head length of DNA detected by using Comet Assay IV Version 4.3.2 for Basler FireWire

Timeframe: postoperative 1 st day