Switching From Ticagrelor to Prasugrel in Patients With Acute Coronary Syndrome (NCT05183178) | Clinical Trial Compass
CompletedPhase 4
Switching From Ticagrelor to Prasugrel in Patients With Acute Coronary Syndrome
Sweden17,095 participantsStarted 2022-02-01
Plain-language summary
This study proposes to conduct the switch from ticagrelor to prasugrel in an organized stepwise manner, to allow for the evaluation of the relative efficacy of prasugrel versus ticagrelor using a stepped-wedge cluster randomized trial design.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients hospitalized for Acute coronary syndrome, as defined by the European Society of Cardiology, at any hospital participating in the study, and included in the SWEDEHEART registry during index hospitalization
* Age ≥ 18 years.
Exclusion Criteria:
* Patients on oral anticoagulation therapy
* Previous stroke
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial looked at switching from ticagrelor to prasugrel in people with acute coronary syndrome — is that kind of switch something that might make sense for my situation, and what would the reasoning be for or against it?
2Since this is a Phase 4 trial that has already completed, has the data been published, and what did it show about the cumulative risk of events when patients switched between these two blood thinners?
3Ticagrelor and prasugrel are both options for treating acute coronary syndrome — how does my doctor decide which one is better for me to start with, and under what circumstances would switching from one to the other ever be considered?
4Are there specific side effects or tolerability issues with ticagrelor that this trial was trying to address by switching to prasugrel, and are any of those issues relevant to my case?
5Would my doctor consider the findings from this completed trial when deciding on my antiplatelet therapy, or is standard guideline-based treatment a more straightforward path for someone in my position?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.