The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis

Inclusion Criteria: UC patients: * M/F, 18-50 y/o * Inactive Disease (Mayo Score ≤ 2) * Stable medications with no disease flares for the \> 3 months * Left-sided UC (Montreal E1 or E2) * Normal psychological evaluation and negative drug screen (See Below) Healthy Controls: * M/F, 18-50 y/o, age ± 3y sex, race, and BMI match with UC subject * No clinical evidence of any medical illness * Normal psychological evaluation and negative drug screen (See Below) Exclusion Criteria: UC patients: * Patients with other forms of colitis such as Crohn's disease (CD) or indeterminate colitis * Patient with active UC (Mayo \> 2) * Pancolonic UC (colitis past the splenic flexure, Montreal E3)) * Use of biologic or immunomodulatory medications (i.e. Infliximab, Adalimumab, azathioprine, Vedolizumab, methotrexate, etc.) * Gastrointestinal surgery * Other GI diseases or systemic diseases (cardiac, renal failure, cirrhosis) * Shift work in the last 6 months * Antibiotic use within last 12 weeks * Patients who have used anti-diarrheal agents such as Lomotil or Imodium within 3 days of the study * Prednisone use the last 30 days * Significant Depression (score ≥ 14 BDI) * Significant Anxiety (score ≥ 40 STAI) * Use of probiotic supplement in last 4 weeks except yogurt. * Intentional change in diet. * Chronic use of NSAIDS. A washout period of 3 weeks is needed before the subject could be enrolled into the study. Low dose aspirin is allowed. * Chronic Alcohol use. A washout period of 3 week…