The Metabolic and Circadian Effects of Shift Work (NCT05177965) | Clinical Trial Compass
CompletedNot Applicable
The Metabolic and Circadian Effects of Shift Work
Switzerland72 participantsStarted 2022-02-01
Plain-language summary
In an exploratory observational pilot study, the investigators will focus on the effects of short-term circadian misalignment induced by shift work on multidimensional measurements including glucose excursion, metabolic health, circadian rhythms (measured in vitro and in vivo), sleep/wake cycles and ambient light, eating and activity patterns, well-being and attention.
Who can participate
Age range
20 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Men and women
* Age 20-50 years
* Working ≥ 80% full-time equivalent over the previous month and during the study
* Working night shifts (i.e. shifts that comprise working hours between 23h and 06h) in rotation with day shifts (i.e. shifts that comprise working hours between 06h and 20h)
* Planned to work at least 3 consecutive night shifts during the study preceded by at least a day off or day shift
* Planned to work at least 3 consecutive day shifts during the study
* Confident use of a smartphone compatible with the study application (iOS, Android) and able to regularly take pictures of consumed food/drinks
* Able to give a fully informed consent and follow the study procedures
Exclusion Criteria:
* Planned or current pregnancy during the study
* Menopausal women
* Major illness or hospitalization over the previous month
* Carries a pacemaker, pump or other medical device that can be disabled by a magnet
* Major mental illness
* Trip to a different time zone (≥ 2-hour time difference) over the previous month or planned during the study
* Enrolled in an interventional clinical trial (potentially interfering with the main outcomes) over the previous month or planned during the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Difference in glucose excursion
Timeframe: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months