CompletedNot Applicable

Interphase Gap in Biphasic Stimulation in DBS for ET

Belgium9 participantsStarted 2021-12-01

Plain-language summary

Deep Brain Stimulation (DBS) is a well established therapy in medication-refractory essential tremor (ET). Since the inception of DBS, cathodic pulses are used. Recent work suggests that biphasic pulses influence the therapeutic window when compared to cathodic pulses, when tested acutely. Animal studies and work from cochlear implants, show that the use of an interphase gap, influences the generation of action potentials. In this study, the goal is to investigate the use of an interphase gap in biphasic pulses in DBS for ET patients.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with essential tremor treated with Vim-DBS * Normal impedances of DBS circuit * Signed written informed consent Exclusion Criteria: * Active psychiatric disease or active alcohol or drug abuse * Dementia * History of recurrent or unprovoked seizures * Relevant comorbidities that influence objective clinical assessment * Pregnancy

What they're measuring

Therapeutic threshold (mA)

Timeframe: During uptitration of the amplitude (entire process takes 3-4 minutes)

Side effect threshold (mA)

Timeframe: During uptitration of the amplitude (entire process takes 3-4 minutes)

Trial details

NCT IDNCT05177900

SponsorMyles Mc Laughlin

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-01-27

View on ClinicalTrials.gov More Essential Tremor trials