Toxicity of Micro and Nano Plastics Combined With Environmental Contaminants on the Risk of Allergic Disease

Inclusion Criteria: * Proven sensitization to at least one food allergen with a diagnosis of at least one allergic disease for at least one year * Clinical diagnosis of allergic rhinitis (AR) for at least 1 year with symptoms of the nose, induced after exposure to allergens via IgE-mediated hypersensitivity reactions (symptoms of watery rhinorrhea, nasal obstruction, nasal itching and sneezing). * Diagnosis of atopic dermatitis (AD) with AD symptoms lasting for more than 3 months, with or without food allergy Additional inclusion criteria: • Significant clinical allergy to indoor and outdoor allergens, an food allergens with positive skin prick test (SPT) and specific IgE levels (\>0.35kUA/L) Exclusion Criteria: * Known inborn or perinatal pulmonary disease; * Pulmonary malformation * Oxygen therapy after birth with a duration of more than 24 h * Ventilator support or mechanical ventilation after birth * Diagnosis of cystic fibrosis * Primary ciliary dyskinesia * Heart failure diagnosed after birth affecting pulmonary circulation * Major respiratory diseases such as e.g. interstitial lung disease and other congenital and serious chronic disease * Fever of at least 38.5 °C during the last two weeks prior to the planned visit