RecruitingNot Applicable

Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis

Switzerland300 participantsStarted 2018-09-04

Plain-language summary

This project is to: 1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients. 2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. 3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. active RRMS (n=100): Relapsing-remitting course and \> 1 clinical relapse and/or signs of MRI activity (\> 1 Gd enhancing lesion) during the last year before study enrollment.
✓. non-active PMS (n=100): Progressive course (PPMS or SPMS) and no clinical relapses and/or signs of MRI activity during the last year before study enrollment.

What they're measuring

MRI- change in axonal integrity and organization over 2 years in aMS, naPMS and HC, by using machine learning techniques

Timeframe: at baseline and 2 years (+/- 3 months) after baseline

Trial details

NCT IDNCT05177523

SponsorUniversity Hospital, Basel, Switzerland

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-12

Contact for this trial

Cristina Granziera, Prof. Dr. med.

+41 61-32 85 665 cristina.granziera@usb.ch

View on ClinicalTrials.gov More Multiple Sclerosis (MS) trials