Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms

Inclusion Criteria: * Volunteers must have a history of mild traumatic brain injury, specifically, persistent post-concussive symptoms after examination by a neuropsychologist or neurologist. * Volunteers time from concussive incident (Mild traumatic brain injury) must be between 3 months - 5 years following head trauma incident * TBI was caused by non-penetrating trauma * Volunteers must have current complaints of TBI symptoms such as headache, dizziness, or cognitive or affective problems * Volunteers must be 18-year-old or more * Willing and able to provide informed consent * Able to speak and read English, as primary language * Agrees to provide blood samples for clinical lab tests * Willing and committed to comply with research protocol and complete all outcome measures * Able to equalize middle ear pressures or willing to undergo needle myringotomies if needed * Willingness and committed to comply with study protocol outlined reproductive plan based on baseline reproductive status Exclusion Criteria: * Prior treatment with hyperbaric oxygen treatment * Hyperbaric chamber inside attendant, professional, SCUBA diver (technical, commercial, operational/military or recreational) * The investigators will exclude pregnant women from this study because potential fetal adverse reactions triggered by high oxygen partial pressures such as retrolenticular fibroplasia though careful review of human data are generally reassuring such as the use of hyperbaric oxygen to treat acute…