Effects of a Machine Learning-based Lower Limb Exercise Training System for Knee Pain (NCT05173064) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effects of a Machine Learning-based Lower Limb Exercise Training System for Knee Pain
Hong Kong176 participantsStarted 2026-05-20
Plain-language summary
The goal of the study is to confirm the idea of AI-powered Technological Surrogate Physiotherapist (TSP), by demonstrating its effectiveness and value as a new technology-based contribution to OA healthcare. Participants will be randomized to one of two groups: (1) the conventional PT group receiving the exercise program delivered through in-person sessions; or (2) the AI-guided group following the program through the TSP after an initial PT session. All individuals will take part in the study for 12 weeks, and data will be collected at baseline and 12 weeks after randomization.
Who can participate
Age range
50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. At least 50 years of age;
. Report having knee pain most days of the week;
. Has radiographic evidence of grade 2, 3, or 4 knee OA on the K-L scale in the posteroanterior and/or skyline view in at least 1 knee;
. Willing and able, both physically and cognitively, to perform the exercises required in the study protocol;
. Has normal or corrected-to-normal vision;
. Able to speak Cantonese and read Chinese, AND
. Able to provide written informed consent.
Exclusion criteria
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial uses a machine learning-based exercise system to manage knee osteoarthritis pain — how does that compare to the standard physical therapy or exercise programs you'd normally recommend for my situation?
2Since this trial isn't recruiting yet, do you know when it might open, and would it make sense for me to start some form of treatment now rather than waiting to see if I qualify?
3The trial measures outcomes using a pain rating scale and a knee function questionnaire called the KOOS — based on where I am right now with my pain and mobility, do you think those would be meaningful measures of improvement for me specifically?
4Because this study is listed as phase 'N/A,' which often means it's testing a device or system rather than a drug, what do you see as the main unknowns about safety or effectiveness that I should weigh before considering something like this?
5Would my current level of knee pain and physical function make me a realistic candidate for an exercise-based trial like this, or do you think my condition might need a different approach first?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Changes in knee pain as assessed by a 11-point numerical pain rating scale as recommended by the OARSI
Timeframe: From baseline to 12 weeks
2
Changes in physical function as assessed by the Knee Injury and Osteoarthritis Outcome Score (KOOS) physical function sub-scale
. Having a history of knee or hip replacement surgery;
. Being nonambulatory;
. Having systemic inflammatory arthritis (e.g., gout);
. Having a history of trauma (e.g., fractures around the knee, dislocation, sprains or tears of soft tissues like ligaments) or surgical arthroscopy of either knee within the past 6 months;
. Having intra-articular injection to the knee within the past 6 months;
. Having cognitive impairment;
. Involvement in a similar study (i.e., involving physical exercise or physical therapies for knee pain) within the past 6 months;
. Undergoing recent or imminent surgery (within 3 months) , OR