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Research of Laser Ablation for the Treatment of Lower Anogenital Tracts' Precancerous Lesions

China200 participantsStarted 2019-11-08

Plain-language summary

Using multiple targeting CO2 laser ablation to treat the precancerous lesion of the female lower anogenital tracts and analyzing the data collected in the study, we aim to form the standard strategy of laser ablation method to increase the effective rate and lower the rate of relapse and progression.

Who can participate

Age range16 Years

SexFEMALE

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Inclusion criteria

✓. Had the history of sexual life.
✓. Transferred to colposcopy examination and biopsy for abnormal screening of cervical cancer, contact bleeding of cervix, recurrent discomfort of vulva or abnormal signs of lower genital and anal tract. The pathology of biopsy indicate CIN, VaIN, VIN, AIN, or PaIN.
✓. If CIN, the colposcopy manifests transformation zone-1 which means the lesion can totally be seen. However the consideration of fertility damage of resection overweighs the chance of suffering cancer.
✓. The patients can accept multiple laser ablations and colposcopy examinations and follow-up at least 2 years.

Exclusion criteria

✕. Patients who are suffering cancers of other systems and in treatment.
✕. Patients suffering acute inflammation of lower genital and anal tracts.
✕. The colposcopy and pathology examination suspect of cancer of lower genital and anal tract.
✕. Patients suffering severe diseases such as insufficiency of liver and kidney function, diseases of blood system and other acute infections who will get heath harm from colposcopy and laser vaporization.

What they're measuring

Pathological cure

Timeframe: up to at least two years

Trial details

NCT IDNCT05170620

SponsorTongji Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-31

Contact for this trial

Shuang Li, Doctor

+86 18971625668 lee5190008@126.com

View on ClinicalTrials.gov More Squamous Intraepithelial Lesions trials