Noninvasive Monitoring of Cerebral Blood Flow Autoregulation
United States14 participantsStarted 2018-04-18
Plain-language summary
Rheoencephalography (REG) shows promise as a method for noninvasive neuromonitoring, because it reflects cerebrovascular reactivity. This protocol will study clinical and technical conditions required to use REG. Additionally, our goal is to study noninvasive peripheral bioimpedance pulse waveforms in order to substitute invasive SAP. A previous study demonstrated that REG can be used to detect spreading depolarization (SD), the early sign of brain metabolic disturbance. SD can be measured invasively with DC EEG amplifiers only. Our goal is to create an automatic notification function for REG monitoring indicating change of clinical conditions.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Intact fronto-temporal area
* Intact lower arm area
* Clinical suspicion of elevated intracranial pressure
Exclusion Criteria:
* N/A
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial has already been completed and was studying noninvasive ways to monitor cerebral blood flow autoregulation, is there published data from it that my doctor could review to understand whether these monitoring techniques might be relevant to my care?
2My condition involves increased intracranial pressure or cerebral edema — can my doctor explain what cerebral blood flow autoregulation means in my specific case and why monitoring it matters for treatment decisions?
3This trial focused on noninvasive monitoring methods, so could my doctor walk me through what monitoring approaches are currently being used for my condition, and whether any noninvasive options are available to me now?
4Since this was listed as phase 'NA,' which sometimes applies to observational or device studies rather than drug trials, can my doctor explain whether the findings from this type of study could affect how my intracranial pressure or cerebral edema is tracked day-to-day?
5Are there other completed or ongoing studies on cerebral blood flow autoregulation monitoring that my doctor thinks are worth looking into, given that this particular trial has already finished enrolling patients?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Cerebral Blood Flow Autoregulation (CBF AR)
Timeframe: through hospital admission, an average of 10 days