Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction (NCT05169541) | Clinical Trial Compass
RecruitingNot Applicable
Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction
Denmark500 participantsStarted 2016-01-01
Plain-language summary
A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure in general, including recurrent implantation failure (RIF) after assisted reproductive technology (ART) (including IVF, ICSI and FET), recurrent pregnancy loss (RPL) after spontaneous conception, and RPL after ART.
Who can participate
Age range
18 Years – 41 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
fulfil one of the following:
* 3 consecutive pregnancy losses after spontaneous conception
* 3 consecutive pregnancy losses after assisted reproductive technology treatment (ART) including IVF, ICSI and FET
* 3 failed embryo transfers characterized by no achieved pregnancy (after 3 cycles with minimum 1 embryo transfer of a good-quality embryo in each cycle.)
Exclusion Criteria:
* Age \<18 or \>45 years
* AMH \<4.0 pmol/l unless donor egg in previous cycles
* Significant uterine malformation
* Known endometrial pathologies including intrauterine endometriosis, adenomyosis, hyperplasia or polyps
* Known chromosomal abnormalities
* Pregnancy \>9 weeks of gestation at the time collecting the blood sample
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Low p-MBL level
Timeframe: Blood sample collected after admission when the patient is not pregnant or <9 weeks of gestation.
2
Very low p-MBL level
Timeframe: Blood sample collected after admission when the patient is not pregnant or <9 weeks of gestation.
3
High p-MBL level
Timeframe: Blood sample collected after admission when the patient is not pregnant or <9 weeks of gestation.