Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia (NCT05164705) | Clinical Trial Compass
CompletedNot Applicable
Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia
United States33 participantsStarted 2022-05-03
Plain-language summary
This study uses magnetic resonance imaging to determine whether 3 weeks of repeated exposure to Acute Intermittent Hypoxia can improve brain blood flow or blood flow regulation in healthy adults.
Who can participate
Age range
21 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy volunteers between ages of 21 and 50 years
* No known neurological, respiratory or vascular conditions
* Safe to be scanned using MRI
* Able to communicate in English
Exclusion Criteria:
* MRI contraindications as indicated on MRI safety screening form
* Subjects with pacemakers, cochlear (in the ear) implants, or aneurysm clips or subjects who have worked with metal
* Pregnant women
* Individuals with known neurological or vascular conditions
* Individuals with sleep apnea, emphysema, or other respiratory conditions
* Individuals with severe claustrophobia
* Subjects unwilling or unable to give written informed consent in English
* Prisoners
* Frequent smoker
* Allergy to Tegaderm
* Blood pressure greater than 140/90 or less than 90/55.
* Individuals who report headaches, feeling dizzy or light-headed, or have heart palpitations on the day of the study.
* Individuals prescribed Aripiprazole and/or Lamotrigine\*
Note, mild (well-controlled) asthma is not immediate grounds for exclusion.
\*Other prescription medications may be grounds for exclusion; prescription medication information will be acquired during initial screening and at subsequent follow-up visits
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.