The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Trainin… (NCT05163600) | Clinical Trial Compass
RecruitingNot Applicable
The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR)
Switzerland24 participantsStarted 2022-05-20
Plain-language summary
The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD.
Regarding secondary objective, the investigators hypothesize that BFR results in lower blood pressure responses compared to traditional exercise training in both healthy and COPD participants.
Who can participate
Age range
18 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion and exclusion for the healthy participants are defined by the following criteria.
Inclusion criteria:
* Age ≥ 18 years
* Clinically healthy
Exclusion criteria:
* Physical or intellectual impairment precluding informed consent or protocol adherence
* Non-German speaking (precluding informed consent)
* Pain during exercise of any origin
* Pregnancy
* History of thromboembolic event in the lower extremity
* Resting systolic blood pressure \<100 mmHg
Inclusion and exclusion for the COPD participants are defined by the following criteria.
Inclusion criteria:
* Age ≥ 18 years
* Diagnosed COPD according to GOLD-guidelines12
Exclusion criteria:
* Physical or intellectual impairment precluding informed consent or protocol adherence
* Non-German speaking (precluding informed consent)
* Acute or recent (within the last 6 weeks) exacerbation of COPD
* Pain during exercise of any origin
* Pregnancy
* History of thromboembolic event in the lower extremity
* Resting systolic blood pressure \<100 mmHg
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Endurance Exercise:(Fixed-Duration Protocol):
Timeframe: Continuously during exercise and at end of exercise, with recovery measurements obtained within 4 minutes post-exercise
Timeframe: Pre-exercise and immediately post-exercise (within minutes after completion of the exercise protocol)
3
Endurance Exercise - COPD Participants (Exhaustive Protocol): Within-subject difference in maximal minute ventilation (VE) between BFR and traditional exercise regimens
Timeframe: Continuously during exercise, at end of exercise (peak value), and within 4 minutes post-exercise
4
Resistance Exercise:(Healthy and COPD): Ventilatory Response (Ventilation, VE)
Timeframe: Continuously during exercise and at end of exercise, with recovery measurements obtained within 4 minutes post-exercise