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Research on the Diagnosis and Treatment of Angle Closure Glaucoma With Abnormal Lens Zonular

China250 participantsStarted 2020-11-01

Plain-language summary

Angle-closure glaucoma is the main type of glaucoma in China, which is divided into acute and chronic angle-closure glaucoma. Previous studies from our group have found that, in lens excision combined with glaucoma surgery, accounted for 46.2% of patients were ligament abnormalities, such as lens subluxation with suspensory ligament relaxation. And it was more common in acute angle-closure glaucoma (55.8%). In acute angle-closure glaucoma, approximately 55.2% of suspensory ligament abnormalities were not diagnosed preoperatively depend on UBM and slit lamp examinations. The purpose of this study was to find a better preoperative diagnosis method of the suspensory ligament abnormality, and to observe the influence of the suspensory ligament abnormality on the occurrence, development and treatment effect of acute angle-closure glaucoma. We plan to collect patients with acute angle-closure glaucoma with monocular onset and exclude traumatic, secondary glaucoma and a history of intraocular surgery. The onset eyes were treated with combined operation, and divided into two groups according to the presence or absence of suspensory ligament abnormalities. The fellow eyes were treated with laser peripheral iridectomy, and followed examination, including UBM, anterior-segment OCT, and IOL master 700, before and after bow excitation test. Then follow up patients every six months. Ultimately, the fellow eyes will be treated with combined surgery after 2.5 years or the fellow eyes occur acute angle-closure glaucoma. In the end, we evaluate the sensitivity and specificity of each index, and the influence of suspensory ligament abnormality on angle-closure glaucoma progression.

Who can participate

Age range45 Years – 79 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. age: 45-79 years old, BCVA\>0.3.
✓. Clinical diagnosis of angle-closure glaucoma, with 19mm\<axial length\<24mm.
✓. Clinical diagnosis of age-related cataract (as control group), with 22mm\<axial length\<26mm.
✓. All the surgeries were finished by the same two experienced ophthalmologists.
✓. The first operated eye was included for observation.

Exclusion criteria

✕. Age-related cataract patients whose anterior chamber depth (ACD)\<2.5mm.
✕. Patients who underwent ocular surgery, such as peripheral iridotomy, trabeculectomy.
✕. Patients with history of ocular trauma.
✕. Patients with other ophthalmic diseases that can cause shallow anterior chamber expect glaucoma and cataract, such as choroid detachment, ciliary body detachment, retinal detachment, bulbar tumor, etc.

What they're measuring

visual acuity (VA)

Timeframe: baseline

visual acuity (VA)

Timeframe: during the procedure

intraocular pressure (IOP)

Timeframe: baseline

intraocular pressure (IOP)

Timeframe: during the procedure

slit-lamp examination

Timeframe: baseline

slit-lamp examination

Timeframe: during the procedure

gonioscopy

Timeframe: baseline

gonioscopy

Timeframe: during the procedure

IOL Master 700

Timeframe: baseline

Trial details

NCT IDNCT05163093

SponsorChunyan Qiao_2021

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-12-31

Contact for this trial

Chunyan Qiao, MD

86-176-1067-8637 chunyan_qiao@163.com

View on ClinicalTrials.gov More Angle-Closure Glaucoma trials

Plain-language summary

Who can participate

Age range45 Years – 79 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. age: 45-79 years old, BCVA\>0.3.
✓. Clinical diagnosis of angle-closure glaucoma, with 19mm\<axial length\<24mm.
✓. Clinical diagnosis of age-related cataract (as control group), with 22mm\<axial length\<26mm.
✓. All the surgeries were finished by the same two experienced ophthalmologists.
✓. The first operated eye was included for observation.

Exclusion criteria

✕. Age-related cataract patients whose anterior chamber depth (ACD)\<2.5mm.
✕. Patients who underwent ocular surgery, such as peripheral iridotomy, trabeculectomy.
✕. Patients with history of ocular trauma.
✕. Patients with other ophthalmic diseases that can cause shallow anterior chamber expect glaucoma and cataract, such as choroid detachment, ciliary body detachment, retinal detachment, bulbar tumor, etc.

What they're measuring

visual acuity (VA)

Timeframe: baseline

visual acuity (VA)

Timeframe: during the procedure

intraocular pressure (IOP)

Timeframe: baseline

intraocular pressure (IOP)

Timeframe: during the procedure

slit-lamp examination

Timeframe: baseline

slit-lamp examination

Timeframe: during the procedure

gonioscopy

Timeframe: baseline

gonioscopy

Timeframe: during the procedure

IOL Master 700

Timeframe: baseline