UnknownNot Applicable

Research on the Diagnosis and Treatment of Angle Closure Glaucoma With Abnormal Lens Zonular

China250 participantsStarted 2020-11-01

Plain-language summary

Angle-closure glaucoma is the main type of glaucoma in China, which is divided into acute and chronic angle-closure glaucoma. Previous studies from our group have found that, in lens excision combined with glaucoma surgery, accounted for 46.2% of patients were ligament abnormalities, such as lens subluxation with suspensory ligament relaxation. And it was more common in acute angle-closure glaucoma (55.8%). In acute angle-closure glaucoma, approximately 55.2% of suspensory ligament abnormalities were not diagnosed preoperatively depend on UBM and slit lamp examinations. The purpose of this study was to find a better preoperative diagnosis method of the suspensory ligament abnormality, and to observe the influence of the suspensory ligament abnormality on the occurrence, development and treatment effect of acute angle-closure glaucoma. We plan to collect patients with acute angle-closure glaucoma with monocular onset and exclude traumatic, secondary glaucoma and a history of intraocular surgery. The onset eyes were treated with combined operation, and divided into two groups according to the presence or absence of suspensory ligament abnormalities. The fellow eyes were treated with laser peripheral iridectomy, and followed examination, including UBM, anterior-segment OCT, and IOL master 700, before and after bow excitation test. Then follow up patients every six months. Ultimately, the fellow eyes will be treated with combined surgery after 2.5 years or the fellow eyes occur acute angle-closure glaucoma. In the end, we evaluate the sensitivity and specificity of each index, and the influence of suspensory ligament abnormality on angle-closure glaucoma progression.

Who can participate

Age range

45 Years – 79 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. age: 45-79 years old, BCVA\>0.3.
. Clinical diagnosis of angle-closure glaucoma, with 19mm\<axial length\<24mm.
. Clinical diagnosis of age-related cataract (as control group), with 22mm\<axial length\<26mm.
. All the surgeries were finished by the same two experienced ophthalmologists.
. The first operated eye was included for observation.

Exclusion criteria

. Age-related cataract patients whose anterior chamber depth (ACD)\<2.5mm.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

visual acuity (VA)

Timeframe: baseline

visual acuity (VA)

Timeframe: during the procedure

intraocular pressure (IOP)

Timeframe: baseline

intraocular pressure (IOP)

Timeframe: during the procedure

slit-lamp examination

Timeframe: baseline

slit-lamp examination

Timeframe: during the procedure

gonioscopy

Timeframe: baseline

gonioscopy

Timeframe: during the procedure

Trial details

NCT IDNCT05163093

SponsorChunyan Qiao_2021

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-12-31

Contact for this trial

Chunyan Qiao, MD

86-176-1067-8637 chunyan_qiao@163.com

View on ClinicalTrials.gov More Angle-Closure Glaucoma trials

Plain-language summary

Who can participate

Age range

45 Years – 79 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. age: 45-79 years old, BCVA\>0.3.
. Clinical diagnosis of angle-closure glaucoma, with 19mm\<axial length\<24mm.
. Clinical diagnosis of age-related cataract (as control group), with 22mm\<axial length\<26mm.
. All the surgeries were finished by the same two experienced ophthalmologists.
. The first operated eye was included for observation.

Exclusion criteria

. Age-related cataract patients whose anterior chamber depth (ACD)\<2.5mm.

What they're measuring

visual acuity (VA)

Timeframe: baseline

visual acuity (VA)

Timeframe: during the procedure

intraocular pressure (IOP)

Timeframe: baseline

intraocular pressure (IOP)

Timeframe: during the procedure

slit-lamp examination

Timeframe: baseline

slit-lamp examination

Timeframe: during the procedure

gonioscopy

Timeframe: baseline

gonioscopy

Timeframe: during the procedure