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Emergent Microsurgical Intervention in Acute Stroke Patients After Mechanical Thrombectomy Failure Trial

Czechia50 participantsStarted 2016-01-01

Plain-language summary

With all of the gains that have been achieved with endovascular mechanical thrombectomy revascularization and intravenous thrombolysis logistics, there is still a subgroup of patients with salvageable brain tissue for whom persistent emergent large vessel occlusion (ELVO) portends a catastrophic outcome. Study aims to test the safety and efficacy of emergent microsurgical intervention in acute ischemic stroke patients with symptomatic middle cerebral artery occlusion after failure of mechanical thrombectomy.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age of ≥ 18 years; * indication for MT according to valid guidelines; * modified Rankin score (mRS) of ≤ 2 before stroke onset; * baseline Alberta Stroke Program Early CT Score (ASPECTS) of ≥ 6; * MCA occlusion in M1 or M2 segment with or without intracranial ICA occlusion; * estimated onset-to-skin cut time of ≤6 h or core/penumbra mismatch in cases with wake-up stroke or stroke with unknown onset; * MT failure with TICI score of 0-1 declared by an interventional neuroradiologist and expectation to achieve recanalization within 24 h from stroke onset. Exclusion Criteria: * indication for MT according to valid guidelines; * thrombocyte count of ≤ 100,000/µL; * contraindication for general anesthesia

What they're measuring

Clinical status at 3 month measured using modified Rankin score

Timeframe: 90 days after randomization

Trial details

NCT IDNCT05153642

SponsorUniversity Hospital Ostrava

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12-31

Contact for this trial

Martin Roubec, MD, PhD

martin.roubec@fno.cz