UnknownNot Applicable

Neurological Complication of Infective Endocarditis: A Prospective Multi-site Cohort Study

200 participantsStarted 2022-01-01

Plain-language summary

The main objective of this study is to better estimate the rate of infectious intracranial aneurysms (IIA) in proved infective endocarditis (IE). It also aims to identify MRI markers capable of accurately predicting (or excluding) IIA; to assess the impact of the different MRI abnormalities on the outcome; to capture the real-world management of EI with neurological complications in comprehensive IE centers in France

Who can participate

Age range18 Years – 100 Years

SexALL

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Inclusion Criteria: * patients with left-sided active infective endocarditis (IE) satisfying modified Duke Criteria, * patients who underwent both digital subtraction angiography (DSA) and brainMRI (as part of routine care) * DSA protocol with 3D rotational for both carotids and one vertebral artery * MRI/MRA standardized protocol including at least: Diffusion, FLAIR, 3D SWI, 3DT1SE and post gadolinium 3DT1SE and 3D TOF (large field: from the vertex to the magnum foramen). Exclusion Criteria: * uncertain diagnosis of IE by infectious disease consultants * patients with chronic IE * MRI performed after the completion of Infectious intracranial aneurysms (IIA) treatment * MRI performed without contrast injection or complete protocol * More than 48-hours delay between performing MRI and DSA

What they're measuring

The assess the occurrence of infectious intracranial aneurysms in proven infective endocarditis

Timeframe: 3 months

Trial details

NCT IDNCT05152225

Sponsorthe Jeunes en Neuroradiologie Interventionnelle (JENI) research group

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2022-03-31

Contact for this trial

Basile Kerleroux, MD-MSc

+33145648222 basile.kerleroux@gmail.com