UnknownNot Applicable

Neurological Complication of Infective Endocarditis: A Prospective Multi-site Cohort Study

200 participantsStarted 2022-01-01

Plain-language summary

The main objective of this study is to better estimate the rate of infectious intracranial aneurysms (IIA) in proved infective endocarditis (IE). It also aims to identify MRI markers capable of accurately predicting (or excluding) IIA; to assess the impact of the different MRI abnormalities on the outcome; to capture the real-world management of EI with neurological complications in comprehensive IE centers in France

Who can participate

Age range

18 Years – 100 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients with left-sided active infective endocarditis (IE) satisfying modified Duke Criteria, * patients who underwent both digital subtraction angiography (DSA) and brainMRI (as part of routine care) * DSA protocol with 3D rotational for both carotids and one vertebral artery * MRI/MRA standardized protocol including at least: Diffusion, FLAIR, 3D SWI, 3DT1SE and post gadolinium 3DT1SE and 3D TOF (large field: from the vertex to the magnum foramen). Exclusion Criteria: * uncertain diagnosis of IE by infectious disease consultants * patients with chronic IE * MRI performed after the completion of Infectious intracranial aneurysms (IIA) treatment * MRI performed without contrast injection or complete protocol * More than 48-hours delay between performing MRI and DSA

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The assess the occurrence of infectious intracranial aneurysms in proven infective endocarditis

Timeframe: 3 months

Trial details

NCT IDNCT05152225

Sponsorthe Jeunes en Neuroradiologie Interventionnelle (JENI) research group

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2022-03-31

Contact for this trial

Basile Kerleroux, MD-MSc

+33145648222 basile.kerleroux@gmail.com

View on ClinicalTrials.gov More Endocarditis, Bacterial trials