RecruitingNot Applicable

Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor

United States120 participantsStarted 2022-06-21

Plain-language summary

The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Clinical indications to proceed with DBS implantation, as determined by the clinical multidisciplinary movement disorders board, including: a) definitive diagnosis of essential tremor or dystonia, b) medically refractory disease, c) adequate performance on neuropsychological evaluation as determined by a licensed clinical neuropsychologist.
✓. The ability to comply with test directions, complete pre-operative task training, and provide informed consent.
✓. Age 18-80 years.

What they're measuring

Correlations between brain signals and intraoperative voice and speech production performance.

Timeframe: 5 years

Changes in standard clinical outcome for dystonia patients

Timeframe: 5 years

Changes in standard clinical outcome for tremor patients

Timeframe: 5 years

Trial details

NCT IDNCT05150093

SponsorMassachusetts Eye and Ear Infirmary

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-08-31

Contact for this trial

Kristina Simonyan, MD, PhD

617-573-6016 simonyan_lab@meei.harvard.edu

View on ClinicalTrials.gov More Laryngeal Dystonia trials