Study in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Occurring After Total Knee Arthroplasty (TKA)

Inclusion Criteria: * Patients with well-fixed prosthesis; * Patients who have a pre- or intra-operative diagnosis of TKA-PJI Exclusion Criteria: * Patients for whom a DAIR procedure is not indicated; * Patients with loose prosthesis and/or surgical treatment requiring removal of well-fixed, non-modular implants at screening; * Patients with previous history or presence of osteomyelitis in the index limb; * Patients who have uncontrolled diabetes mellitus; * Patients with body mass index \>50 kg/m2 at screening; * Patients who are immunosuppressed; * Patients who require therapeutic anticoagulation and/or antiplatelet therapy