CompletedNot Applicable

The Effect of Volatile Anesthesia and Total Intravenous Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Mastectomy and Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Free Flap

South Korea50 participantsStarted 2021-05-21

Plain-language summary

The aim of this study was to investigate the effects of total intravenous and inhalation anesthesia on the damage of endothelial glucocorticoids by comparing the concentration of syndecan-1 in patients undergoing mastectomy and breast reconstruction using deep inferior epigastric artery perforator free flap

Who can participate

Age range20 Years

SexFEMALE

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Inclusion criteria

✓. Adult patients over 20 years old with ASA class I-III
✓. Scheduled total mastectomy and deep inferior epigastric artery perforator flap breast reconstruction

Exclusion criteria

✕. emergency surgery
✕. Bilateral deep inferior epigastric artery perforator flap breast reconstruction
✕. patients unable to make their own decisions, illiterate, foreigners
✕. Allergy / hypersensitivity to sevoflurane or propofol 5, Current or past history or thrombosis / thromboembolism

What they're measuring

Changes in blood concentration of syndecan-1

Timeframe: 1) 10 minutes after anesthesia induction <before surgery(base concentration)> 2) 10 minutes after sitting position 3) 1 hour after surgery

Trial details

NCT IDNCT05136508

SponsorYonsei University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-11-13

View on ClinicalTrials.gov More Deep Inferior Epigastric Artery Perforator Flap Breast Reconstruction trials