Role of Antioxidants in the Reduction of Oxidative Stress in Infertile Patients

Inclusion Criteria: * age, 19-45 years; * infertility, 2 years; * regular sexual intercourse with a fertile female. * The female partner was defined as being fertile if she had undergone a negative infertility workup (biphasic basal body temperature, P evaluation in luteal phase, ultrasound ovary and uterus evaluation, and hysterosalpingogram to study tubal patency) Exclusion Criteria: * use of antioxidant agents or vitamins within 8 weeks prior to inclusion in the study, * a history of excessive consumption of alcohol 40 days prior to the start of the trial, * patients that showed lower than 5% motility and less than 1 × 106/ml sperm concentration, - patients with any acute or chronic disease or * who are undergoing some kind of treatment with any class of drugs and * subjects with known hypersensitivity to ingredients in the antioxidant formula.